Brought 3 friends along with me and we all enjoyed the 101 class! Ashley is a great instructor and made it fun to learn the game. We're excited to return for the 102 class next month.
High Performance Face Cream
High Performance Face Cream
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$225.00 USD
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$225.00 USD
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High Performance Face Cream Formulated by Dr. Macrene Alexiades, MD, PhD · Dual Board-Certified Dermatologist & Research Scientist
Architectural support for the skin — built around ingredients almost nobody else in skincare will work with.
The High Performance Face Cream is not a moisturizer in the conventional sense. It is a structural treatment in cream form, anchored by the patented MA37® complex — Dr. Alexiades's proprietary system of 37 classes of actives that defines every formula in the collection — and elevated here by two of the most technically demanding and rarely used ingredients in modern dermatology: copper lysinate/prolinate and a Plankton, Micrococcus, Arabidopsis DNA repair system that sits at the frontier of skin science.
Where the High Performance Serum delivers intensive correction and lifting, this cream works beneath the surface to reinforce what holds skin together: barrier integrity, collagen architecture, elasticity, and sustained hydration.
Think of it as the foundation your serum builds on.
Key Actives
MA37® patented complex — The scientific foundation of the entire DR. MACRENE actives line. MA37® refers to Dr. Alexiades's patented system of 37 classes of actives — the broadest multi-pathway approach to skin aging in the collection, addressing firmness, hydration, barrier integrity, environmental defense, cellular repair, and luminosity simultaneously. Every product in the line is built on this architecture. The cream deploys it in full.
Copper lysinate/prolinate — a rarely used, technically demanding copper peptide — Not all copper peptides are equal. This is copper chelated to lysine and proline — the precise amino acid building blocks of collagen — making it exceptionally bioavailable, stable, and targeted in a way standard copper peptide forms are not. Once absorbed, it directly stimulates collagen and elastin synthesis and accelerates skin repair at the fibroblast level. It is one of the most clinically validated actives in dermatology — and one of the least used in skincare, because its stability requirements and cost make it difficult to formulate with correctly. Dr. Alexiades formulated with it anyway, because the clinical evidence left no other choice.
Plankton, Micrococcus, Arabidopsis DNA repair system — the ingredients almost no one works with — Marine and terrestrial plant enzyme extracts with a scientifically documented ability to repair UV-induced DNA damage in skin cells — the cumulative damage that, left unaddressed, drives accelerated aging, loss of firmness, and long-term structural breakdown. It is costly, pH-sensitive, reactive with common preservative systems, and technically demanding to keep stable in a finished formula. Very few formulators attempt it. Dr. Alexiades includes it because the mechanism is irreplaceable and her scientific background gives her the tools to do it right.
Ergothioneine — One of the most potent and stable antioxidants known to science, with a dedicated cellular transporter in human skin. Protects mitochondrial DNA from oxidative damage and has been associated with slowing the cellular aging process itself. Rarely seen in skincare due to its cost and sourcing complexity.
Organic mushroom extract (Tremella fuciformis) — A botanical hyaluronic acid alternative with superior water-holding capacity, delivering deep sustained hydration while supporting the skin's own moisture regulation mechanisms.
Olive-derived lipids & squalane — Structurally similar to the skin's own lipid barrier, these replenish the protective layer that locks moisture in and keeps environmental aggressors out, restoring suppleness without heaviness.
Antioxidant complex — Edelweiss, microalgae, plankton, green coffee, yerba mate, feverfew, resveratrol, and stabilized vitamin C form a comprehensive defense against the oxidative stress that degrades collagen, accelerates fine lines, and diminishes radiance over time.
Full amino acid complex — Mirrors the skin's own natural moisturizing factors to continuously restore softness, barrier integrity, and the appearance of smooth, healthy skin.
How It Works With Your Routine
The High Performance Face Cream is the second step in Dr. Alexiades's two-product treatment system:
Serum → intensive correction, lifting, and active delivery
Cream → barrier reinforcement, structural support, and moisture lock
The serum opens the pathway. The cream seals and rebuilds. Used together, they address skin aging at every level — from cellular repair to surface resilience.
The Science Behind the Formula
Most luxury creams compete on texture and fragrance. Dr. Alexiades competed on mechanism. The MA37® complex is the product of her clinical and scientific research — a patented approach that targets the skin's own repair pathways rather than simply sitting on the surface. The copper lysinate/prolinate and Micrococcus lysate at its core are not shortcuts — they are the hardest ingredients in this formula to source, stabilize, and deliver effectively. They are here because a physician with a PhD looked at the evidence and decided that difficulty was not a reason to leave them out.
What You Will See
Immediately: Deeply hydrated, visibly smoother skin with a restored, supple feel.
With regular use: Measurably firmer skin, softened fine lines and wrinkles, reduced redness, strengthened barrier function, and a sustained revitalized glow that reflects structurally healthier skin beneath the surface.
Ingredients
Ingredients
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Customer Reviews
Overall rating: 4.7 / 5 from 240 reviews.
Gives me the perfect plump lip look without overdoing it perfect for daily use, loving all the colors
I had a wonderful time and learned how to play mahjong. The class was so informative.
This mat went so beautifully with my new tiles! So happy with it! Love that it came with a tube to store it in! The size is wonderful at 33X33. Got so many compliments on it!
Smells amazing!!!
Love the oil!! It’s my second time purchasing. I initially bought it in a small boutique and after a diligent Internet search, I found you guys and purchased through you. This time, I bought the larger bottle, but the pump that was sent does not fit the bottle.
Love this color. It feels like it moisturizes too.
One of the best concealers that I have tried! The consistency is really nice and it’s really easy to blend and mix with the other products!
Great class
Fun class!
I attended the Jane Iredale makeover session at the shop and instantly fell in love with this lip shade! The color worked so well with my complexion and stays on for hours. Even after eating and drinking you're left with a beautiful stain on the lips. 10/10 recommend!
My skin is line free .absolutely love this oil as it works miraculously.❤️
My kids love this! This is our third bottle we’ve purchased and every time we run out they beg for more. This is our first time trying a different fragrance and it did not disappoint.
Soothing and made with high quality material. Feels good in my hand. Would buy again.
Nice customer service
Beautiful set that I bought for a friend! She absolutely loves them. We just played a round with them last week!
The best lotion for my hands. It has the best absorption, light fragrance, and fantastic texture when first applying it. I use it daily!
So I love that this tint is natural and I like to try new items in the store as there are limited chemicals. This stain is great for an evening out or even one coat to go to work daily. However, it transfers and only lasts 1-2 hours before you need to reapply. It's a pigmented finish and usually I see color left on the outlines of my lips.
Purchased the sample size and will be upgrading to the full bottle. It smells wonderful, not overpowering and will not bother your sinuses or give headaches.
I love my new deodorant! I will be a regular, thank you.
Ashley is great we had a great time signed up for 102. Can't wait for next class.
This stuff gives such good protection for my extremely sun-sensitive lips. So grateful for this shade - perfect for neutral toned skin. it looks good, without shouting "I'M WEARING LIPSTICK!" I've tried Berry (a bit too cool for me) and Red Earth (a bit too warm) before, and Nude is just right.
Great foundation. It is easy to apply and it does not feel itchy on my skin.
Really helps get me back to sleep if I wake up during the night.
Pretty color and worked well for my sensitive eyelids. Thanks to Anisa for introducing me to the brand!!
Love the glow that this adds to my skin for summer.
Love this makeup and couldn’t find it anywhere. Great shopping and product. On time.
Great cream with a subtle smell, but very effective and easy on the skin.
This is such a great compact little brush! Very high quality and I loved that I was able to check to see if it was available at my closest store and then run past and pick up from Ashley!
I was happy to really understand the NMJL card!
i love it honestly
Love it but disappointed in delivery.. wrong product… return will be sent to fed ex asap
Ashley was fantastic , super patient and helpful. Enjoyed the small, very personal group with ladies my own level of experience.
Can't wait to sign up for 103! Looking forward to open play as well. Thank you for a great evening and lots of mind blowing instructions.
I love my tile that I bought from ashley. However, I have not used them yet. I would certainly recommend.
This is, by far, my favorite face oil. Super hydrating and soaks in quickly.
Smells amazing!
They are a gift for a friend to take on a cruise. She is teaching her companions Mah Jong so these cards should be perfect
My wife loves the design and the smell and it came very fast! Thank you!
The scent is just what I was hoping. It closely compliments Scottish Honey Rum cream.